A Newly Developed Synbiotic Yogurt Prevents Diabetes by Improving the Microbiome–Intestine–Pancreas Axis

The prevalence of type 2 diabetes mellitus (T2D) is increasing worldwide, and there are no long-term preventive strategies to stop this growth. Emerging research shows that perturbations in the gut microbiome significantly contribute development T2D, while modulators may be beneficial for T2D prevention. However, effective, safe, affordable, able administered daily not yet available. Based on our previous pro- prebiotic studies, we developed a novel synbiotic yogurt comprised human-origin probiotics plant-based prebiotics investigated its impact diet- streptozotocin-induced mice. We compared effects those commercially available (control yogurt). Interestingly, found feeding reduced hyperglycemia (diabetes) response high-fat diet streptozotocin milk-fed controls. Surprisingly, control exacerbated progression. Synbiotic beneficially modulated microbiota composition milk, negatively it by abundance detrimental bacteria such as Proteobacteria Enterobacteriaceae. In addition, protected pancreatic islet morphology milk control, demonstrated worse islets. These results suggest newly protects against mice can used therapeutic prevent